Orenda Immune + Detox®

If you've tried immune supplements before and still don't feel like your immune system is keeping pace, you're not imagining things. Most immune supplements are doing something, just not enough of what actually matters.

Here's what most of them don't tell you. Fueling the immune system and supporting its coordination are two very different things. Vitamins, herbs, and antioxidants give your body's defenses something to work with. That's useful. But a well-fueled and supported immune system that isn't coordinating properly still can't support the response your body needs.* And an immune system managing a significant daily toxic burden is one that's already under demand before anything else comes along.

Orenda Immune + Detox® addresses both of those realities, and most immune formulas address neither.

IMMUSE® (LC-Plasma) is the first dietary ingredient clinically shown to support plasmacytoid dendritic cell activity.* pDCs are among the rarest and most important cells in the immune system. When they are supported, they signal a coordinated response across both the innate and adaptive immune arms , supporting natural killer cells, killer T cells, helper T cells, and B cells working together rather than just one cell type working alone.* This is what whole-system immune support actually looks like, not overstimulating the immune system, but supporting its natural coordination so it can respond appropriately when needed.*

Calcium d-glucarate supports glucuronidation, the liver's primary detoxification pathway, helping the body clear toxins and excess hormones daily rather than recirculating them.* Because a body carrying a high toxic burden is an immune system that's perpetually occupied. Clearing that burden is one of the most overlooked components of genuine immune support.*

After more than two decades and thousands of immune products on the market, this formula exists because Orenda asked a different question, not just how to fuel the immune system, but what was getting in the way of it working properly in the first place.

That's still a question most immune supplements haven't thought to ask.

IMMUSE® (LC-Plasma) is a postbiotic — a heat-treated, non-viable form of the lactic acid bacteria Lactococcus lactis strain Plasma. Unlike a probiotic, IMMUSE® doesn't need to be alive to work. The heat treatment process preserves its immune-supporting properties while making it shelf-stable, allergen-free, and suitable for a wide range of dietary needs.*

Most immune supplements target natural killer cells, one cell type in one arm of the immune system. IMMUSE® works differently. It is the first dietary ingredient clinically shown to support plasmacytoid dendritic cell (pDC) activity.* pDCs are among the rarest and most important cells in the immune system, when they are supported, they signal a coordinated response across both the innate and adaptive immune arms, supporting the body's natural defenses at the cellular level.*

The science behind dendritic cells earned a Nobel Prize. In 2011, Dr. Ralph Steinman of Rockefeller University was awarded the Nobel Prize in Physiology or Medicine for his discovery of the dendritic cell and its foundational role in adaptive immunity, research that opened the door to understanding how cells like pDCs direct the immune system's broader response.

IMMUSE® has been validated in 30 published studies, including 15 human clinical trials, all of which are double-blind and placebo-controlled. It has been shown to support year-round immune health and immune resilience during periods of physical and mental stress.* It can be taken with or without food, at any time of day, and does not require refrigeration.

Developed by Kirin Holdings and Kyowa Hakko, a company with more than 130 years of fermentation science expertise, IMMUSE® is non-GMO, dairy-free, gluten-free, and self-affirmed GRAS.*

Calcium d-glucarate supports glucuronidation — the liver's primary detoxification pathway. Glucuronidation works by binding toxins and excess hormones to glucuronic acid, making them water-soluble so the body can clear them through normal elimination. It's one of the most important and most overlooked detoxification processes the body runs every day.

The reason supplementing with calcium d-glucarate matters is what happens without adequate support. An enzyme produced by certain gut bacteria, called beta-glucuronidase, can interfere with glucuronidation, essentially splitting the bond between processed toxins and the compounds that carry them out of the body. When that happens, those toxins are reabsorbed into circulation rather than eliminated, creating a recycling loop that adds to the body's overall toxic burden over time.

Calcium d-glucarate helps inhibit beta-glucuronidase activity, keeping that recycling loop from running and supporting more complete toxin clearance.* It also supports healthy hormone metabolism, helping the body clear excess estrogen and environmental estrogen mimickers that accumulate through diet, environment, and natural hormonal shifts.* This is particularly relevant for adults navigating midlife hormonal changes, when the body's natural detox channels are under greater demand.*

Research also suggests that calcium d-glucarate supports a balanced inflammatory response, an important consideration given the close connection between immune function and inflammation.* When the body's detoxification pathways are working well, the immune system is better positioned to respond appropriately rather than remaining in a state of ongoing activation.*

This is why detoxification belongs in an immune formula. A body managing a high toxic burden is an immune system already working overtime, and calcium d-glucarate addresses that burden directly, every day.*

Beta-1,3 glucan from organic oat bran is a soluble fiber that interacts with immune cell receptors throughout the body, specifically on macrophages, neutrophils, and natural killer cells, supporting the immune system's natural, everyday defense function.* These are the frontline cells of the innate immune response, and beta-1,3 glucan is one of the most well-studied ingredients for supporting their activity.*

Gut health and immune health are more closely connected than most people realize. Roughly 70% of the immune system resides in the gut, which is why it matters that beta-1,3 glucan also functions as a prebiotic fiber nourishing the beneficial bacteria in the digestive system that the immune system depends on.* Supporting the gut microbiome is supporting immune health from the inside out.*

Beta-1,3 glucan from oat bran has also been studied for its role in supporting healthy cholesterol levels already within the normal range and contributing to cardiovascular well-being*, a benefit backed by decades of published research. Sourced from organic oat bran rather than mushrooms, it's clean, non-GMO, and naturally gluten-free.

Oats are naturally free of gluten, though cross-contamination during processing is a real concern with many oat-based products. Every batch of Orenda Immune + Detox® is tested to confirm it meets the FDA standard of less than 20 parts per million of gluten.*

The organic oat bran used in this formula is also non-GMO and suitable for both vegetarian and vegan lifestyles.

Those with celiac disease or significant gluten sensitivity should consult with a healthcare provider before adding any oat-based product to their routine.

If you've ever looked at a supplement label and wondered what the capsule itself is made of, that's exactly the right question to ask. The capsule matters more than most people realize.

Orenda uses HPMC capsules, made from hypromellose — a plant-based material derived from wood pulp cellulose. Unlike traditional gelatin capsules, which are made from animal collagen, HPMC capsules are 100% plant-based and suitable for vegetarian and vegan lifestyles.

They also protect what's inside more effectively. HPMC has a naturally low moisture content, which helps shield sensitive ingredients from humidity and heat, keeping the formula stable from production to the moment you open the bottle. No additives, no preservatives, nothing that doesn't need to be there.

Sourced from a renewable plant material, this formulation detail reflects the same care and attention that goes into every ingredient in this formula.

Yes — Orenda Immune + Detox® is formulated for daily, ongoing use. IMMUSE® (LC-Plasma) is self-affirmed GRAS (Generally Recognized as Safe) by an independent panel of qualified scientists, and has been extensively studied for both safety and efficacy.* Calcium d-glucarate and organic beta-1,3 glucan from oat bran are both well-studied, naturally occurring compounds with strong safety profiles documented across decades of published research.*

Daily consistency is also central to how this formula works. The immune system benefits from ongoing support rather than periodic or reactive supplementation, and the detoxification support from calcium d-glucarate is most effective when taken regularly as part of a daily routine.*

As with any supplement, those who are pregnant, nursing, managing a specific health condition, or taking any medications should consult with a healthcare provider before use.

Orenda Immune + Detox® is formulated with high-quality, well-researched ingredients and is generally well-tolerated.* That said, if you are currently under medical care or taking any medications, we recommend consulting with your healthcare provider before adding any new supplement to your routine. Your healthcare provider understands your full health picture and is the right person to make that call with you.

🎥 Ultimate Knowledge Spotlight - Orenda Immune + Detox® with Dr. Golden, MD (2min)

🎥 Ultimate Knowledge Spotlight - Toxin Issues with Dr. Lu, MD, PhD. (2min)

🎙️ In-depth Dive on Orenda Immune + Detox® with co-Founder George Hall (15min)

🎙️ Indepth Dive on the Orenda Detox System with co-Founder George Hall & Dr Lu (29min)