Orenda Immune + Detox®

IMMUSE® (LC-Plasma postbiotic) IMMUSE® supports plasmacytoid dendritic cell (pDC) activity, rare immune cells that coordinate a broad response across both the innate and adaptive immune systems.* Backed by 30 published studies, including 15 human clinical trials, it is the first dietary ingredient clinically shown to work at this level of immune coordination.*

Calcium d-glucarate supports glucuronidation, the liver's primary detoxification pathway, helping the body clear toxins and excess hormones rather than reabsorbing them back into circulation.* Addressing the daily toxic burden the modern body carries is one of the most overlooked components of genuine immune support.*

Organic beta-1,3 glucan from oat bran supports immune cell function throughout the body and acts as a prebiotic fiber, nourishing the beneficial bacteria in the gut where most of the immune system resides.* Sourced from organic oat bran, clean, non-GMO, and naturally gluten-free.*

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You're not someone who ignores your health. You pay attention to what you eat, you move your body, and you take your supplements. And still, there are stretches when your immune system feels like it's just not keeping up. You get knocked down, and it takes longer than it should. Or you never quite get knocked down, but you never quite feel sharp either. Something is off, and you can't point to exactly what.

What most immune supplements don't tell you is that fueling the immune system and directing it are two very different things. Vitamins, herbs, and antioxidants give your body's defenses something to work with. That matters. But a well-fueled immune system that isn't coordinating properly still can't mount the response your body needs. And an immune system managing a significant toxic burden, environmental chemicals, excess hormones, metabolic waste accumulating faster than the body can clear it, is an immune system already stretched thin before anything else comes along.

Orenda Immune + Detox® has been our flagship immune product for more than two decades, trusted by healthcare providers and the people they care for. Not because it follows the standard immune supplement playbook, but because it doesn't.

The coordination problem and what IMMUSE® does about it

Your immune system has two arms. The innate response is immediate and broad, your body's first line of defense. The adaptive response is learned and specialized, building over time as your immune system encounters and remembers different challenges. For a meaningful immune response, both arms need to work together.

For decades, most immune supplements targeted natural killer cells — one cell type, one arm. That's partial support. It's not nothing, but it leaves a significant gap.

IMMUSE® (LC-Plasma) works at a different level entirely. It is the first dietary ingredient clinically shown to support plasmacytoid dendritic cell (pDC's) activity.* They are among the rarest and most important cells in the immune system; when they are supported, they signal a coordinated response across both the innate and adaptive arms, preparing the body's natural defenses from the inside out.*

The science behind dendritic cells earned a Nobel Prize. In 2011, Dr. Ralph Steinman of Rockefeller University was awarded the Nobel Prize in Physiology or Medicine for his discovery of the dendritic cell and its foundational role in adaptive immunity, research that opened the door to understanding how cells like pDCs direct the immune system's broader response.

Backed by 30 published studies, including 15 human clinical trials, IMMUSE® has been shown to support year-round immune health and immune resilience during periods of physical and mental stress.*

Why detoxification belongs in an immune product

This is the part most immune formulas skip entirely, and it may be the most important part.

The immune system cannot perform well under a high toxic load. When the body is managing a constant stream of environmental toxins, excess hormones, and metabolic waste, the immune system is perpetually occupied. It's chronically signaling, chronically working, and never fully resolving. That low-grade, ongoing immune activation is one of the most common and least discussed reasons people feel like their immune system isn't quite right.

The liver is the body's primary filter. It processes toxins through a pathway called glucuronidation, binding them to compounds that make them water-soluble and ready for elimination. But an enzyme produced by certain gut bacteria can interfere with that process, recycling toxins back into circulation before they actually leave the body. The result is accumulation, a toxic burden that quietly undermines immune function over time.

Calcium d-glucarate supports the glucuronidation pathway, helping ensure that what the liver processes actually gets cleared.* It supports healthy hormone metabolism, including excess estrogen, which accumulates in both men and women through diet, environment, and natural hormonal shifts, helping remove what the body no longer needs rather than recirculating it.* And it helps keep the recycling loop from running, so the body can actually finish what it starts.*

After more than two decades and thousands of immune products on the market, Orenda Immune + Detox® remains the only immune formula that includes a dedicated detoxification component. That's not an accident. It's a formulation decision rooted in understanding why the immune system struggles in the first place.

The role of organic beta-1,3 glucan from oat bran

Most people don't immediately connect gut health to immune health, but they should. The gut is home to most of the immune system. The bacteria that live there play a direct role in how effectively the immune response functions, how well toxins are cleared, and how consistently the body maintains its natural balance.

Beta-1,3 glucan from organic oat bran supports immune cell function throughout the body by interacting with receptors on macrophages, neutrophils, and natural killer cells, the cells responsible for the immune system's frontline, everyday defense.* It also acts as a prebiotic fiber, feeding the beneficial bacteria in the gut that the immune system depends on.*

Sourced from organic oat bran, it's clean, non-GMO, and naturally gluten-free, and it rounds out a formula that works on three distinct levels at once.

What two decades of conviction looks like

Three ingredients. Three mechanisms. One complete approach to what immune health actually requires.

IMMUSE® coordinates the immune response at the cellular level. Calcium d-glucarate addresses the toxic burden that undermines it. Organic beta-1,3 glucan supports the frontline immune cells and the gut microbiome that houses most of the system. Two capsules daily. No complicated protocol.

The healthcare providers who work most closely with this formula, the integrative practitioners, the functional medicine physicians, the clinicians who have spent careers asking why the immune system struggles, have been recommending Orenda Immune + Detox® for over two decades. They've read the research. They've seen the results with their own patients. And when science advanced, they were the first to recognize why
it mattered.

That depth of clinical conviction isn't something that gets manufactured. It gets earned, over time, by a formula that keeps delivering.

This is where supporting immune health gets taken seriously.

Recommended intake: As a dietary supplement take two capsules daily for the best results, or as directed by a physician.