Orenda Ultimate Bundle

Before a supplement can do anything useful, it has to survive the journey through your digestive system, stomach acid, digestive enzymes, and a complex intestinal environment that can degrade nutrients before they ever reach the bloodstream. Traditional supplements can lose a meaningful portion of their potency in that process.

Liposomal delivery addresses this directly.

Each key nutrient is enclosed within a liposome, a tiny sphere made from phospholipids, the same healthy fats found in your cell membranes. This protective layer helps ingredients remain stable as they move through the body and supports their absorption from the moment of ingestion. Orenda uses sunflower-based phospholipids specifically, a clean, plant-derived source that is non-GMO, soy-free, gluten-free, and dairy-free, and carries Generally Recognized as Safe (GRAS) status. Many phospholipid sources are soy-derived, making the soy-free distinction worth noting for anyone mindful of soy in their supplement routine. It's a deliberate choice that reflects Orenda's commitment to a cleaner, more inclusive formula.

Where conventional supplements are exposed to the digestive process from the moment they're swallowed, liposomal nutrients travel in a form designed to hold up, so more of what you're taking has the opportunity to be absorbed and used.

Calcium d-glucarate supports glucuronidation, the liver's primary detoxification pathway. Glucuronidation works by binding toxins and excess hormones to glucuronic acid, making them water-soluble so the body can clear them through normal elimination. It's one of the most important and most overlooked detoxification processes the body runs every day.

The reason supplementing with calcium d-glucarate matters is what happens without adequate support. An enzyme produced by certain gut bacteria, called beta-glucuronidase, can interfere with glucuronidation, essentially splitting the bond between processed toxins and the compounds that carry them out of the body. When that happens, those toxins are reabsorbed into circulation rather than eliminated, creating a recycling loop that adds to the body's overall toxic burden over time.

Calcium d-glucarate helps inhibit beta-glucuronidase activity, keeping that recycling loop from running and supporting more complete toxin clearance.* It also supports healthy hormone metabolism, helping the body clear excess estrogen and environmental estrogen mimickers that accumulate through diet, environment, and natural hormonal shifts.* This is particularly relevant for adults navigating midlife hormonal changes, when the body's natural detox channels are under greater demand.*

Research also suggests that calcium d-glucarate supports a balanced inflammatory response, an important consideration given the close connection between immune function and inflammation.* When the body's detoxification pathways are working well, the immune system is better positioned to respond appropriately rather than remaining in a state of ongoing activation.*

This is why detoxification belongs in an immune formula. A body managing a high toxic burden is an immune system already working overtime, and calcium d-glucarate addresses that burden directly, every day.*

Beta-1,3 glucan from organic oat bran is a soluble fiber that interacts with immune cell receptors throughout the body, specifically on macrophages, neutrophils, and natural killer cells, supporting the immune system's natural, everyday defense function.* These are the frontline cells of the innate immune response, and beta-1,3 glucan is one of the most well-studied ingredients for supporting their activity.*

Gut health and immune health are more closely connected than most people realize. Roughly 70% of the immune system resides in the gut, which is why it matters that beta-1,3 glucan also functions as a prebiotic fiber, nourishing the beneficial bacteria in the digestive system that the immune system depends on.* Supporting the gut microbiome is supporting immune health from the inside out.*

Beta-1,3 glucan from oat bran has also been studied for its role in supporting healthy cholesterol levels already within the normal range and contributing to cardiovascular well-being*, a benefit backed by decades of published research. Sourced from organic oat bran rather than mushrooms, it's clean, non-GMO, and naturally gluten-free.

Standard probiotic strains can be vulnerable to heat, moisture, and acidity, which means many may not reach the colon in their most active state — where probiotic strains do their most meaningful work.* Endospore-forming Bacillus strains are structurally different. Their natural spore formation makes them acid-resistant and stable through normal storage conditions and the full journey through the digestive system.*

Orenda Eaze® uses a custom blend of three specifically selected Bacillus endospore strains — part of the formula's broader 13-strain probiotic blend. Bacillus coagulans is the most extensively researched of the three, with strong support for digestive comfort, regularity, and microbiome balance.* Bacillus clausii is particularly noted for its resilience — its spores remain stable in gastric conditions that challenge many other probiotic strains* — and for its role in microbiome restoration.* Bacillus subtilis supports gut microbiome diversity and gut barrier function,* while also producing postbiotic metabolites that contribute to the formula's broader gut health benefits.*

Three strains. Three distinct contributions. One formula built to deliver probiotic support that reaches where it matters most.*

The serrapeptase in Orenda Eaze® is a proteolytic enzyme with over 50 years of use and an established body of research in international clinical literature. As a systemic enzyme, it is absorbed from the small intestine into the bloodstream, where it supports the body as a whole rather than working only in the digestive tract.*

Serrapeptase is sensitive to stomach acid — without protection, a meaningful portion of enzyme activity can be lost before reaching the small intestine, where absorption occurs. The acid-resistant enteric coating in Orenda Eaze® protects serrapeptase as it passes through the stomach and releases it into the alkaline environment of the small intestine, where absorption occurs.*

Serrapeptase is both proteolytic and fibrinolytic — a proteolytic enzyme that supports the body's natural metabolic processes and overall tissue health.* As the systemic enzyme in this formula, it brings a layer of support that reaches well beyond digestion.*

GABA — gamma-aminobutyric acid — is a neurotransmitter the body produces naturally. It plays a key role in calming nervous system activity, supporting relaxation, and contributing to the quality of rest the body needs for its natural overnight recovery processes.*

Most GABA supplements use a synthetic form that research suggests may not cross the blood-brain barrier effectively, limiting how much benefit actually reaches the nervous system. PharmaGABA® is different. It is produced through a natural fermentation process using Lactobacillus hilgardii, the same beneficial bacteria used in traditional food fermentation, resulting in a form of GABA that research suggests is more readily recognized and utilized by the body.*

In O-Tropin®, PharmaGABA® supports relaxation and calm nervous system activity,* and contributes to restorative sleep when experiencing occasional sleeplessness.* It is produced without artificial ingredients or fillers, and carries a clean safety profile backed by published research.

For adults navigating the sleep and stress challenges that often accompany midlife, PharmaGABA® is one of the most credible and well-researched natural support ingredients available.*

Coenzyme Q10 — CoQ10 — is a naturally occurring compound found in every cell in the body. Its primary role is supporting the production of adenosine triphosphate (ATP), the form of energy the body's cells run on.* CoQ10 is particularly concentrated in the heart, brain, and muscles, the organs and tissues with the highest energy demands.*

The body produces CoQ10 naturally, but that production tends to decline with age, a shift that can affect energy availability at the cellular level.* Supplementing with CoQ10 supports the body's natural energy production processes and contributes to cardiovascular and overall cellular well-being.*

Both Orenda Active® and Orenda Women's® include CoQ10 as part of a formulation built around ingredient depth rather than minimum effective doses. For adults navigating midlife and beyond, maintaining adequate CoQ10 levels is one of the more well-supported strategies for supporting sustained energy and cellular health.*

Most supplements contain only one or two forms of vitamin E — typically alpha-tocopherol, which is the most common and least expensive form. But vitamin E is actually a family of eight distinct compounds: four tocopherols (alpha, beta, gamma, and delta) and four tocotrienols (alpha, beta, gamma, and delta). Each form has its own specific role in the body, and research suggests that tocotrienols in particular offer benefits that tocopherols alone cannot provide.*

Orenda Active® and Orenda Women's® include all eight forms — alpha-tocopherol, beta-tocopherol, gamma-tocopherol, delta-tocopherol, alpha-tocotrienol, beta-tocotrienol, gamma-tocotrienol, and delta-tocotrienol — because complete vitamin E support requires the full spectrum, not just the most common form.* This is a formulation decision that reflects Orenda's commitment to ingredient depth over convenience.

Folate is an essential B vitamin that supports cell function, DNA synthesis, and healthy development.* But the form of folate matters as much as the folate itself. Most supplements use folic acid, a synthetic form that the body must convert into its active, usable form, L-5-methyltetrahydrofolate (L-5-MTHF), before it can be utilized.*

For roughly one-third of people, a common genetic variation affects the enzyme responsible for that conversion, meaning standard folic acid supplements may not be fully utilized by the body. Methylated folate, as L-5-MTHF, bypasses that conversion step entirely; it's already in the active form the body can use directly.*

Orenda Women's® uses BioFolate®, a branded, clinically researched form of L-5-MTHF methylated folate, ensuring the folate in this formula is bioavailable regardless of genetic variation.* Orenda Active® also uses methylated folate for the same reason. It's a formulation decision that reflects the kind of ingredient depth that makes a meaningful difference for the people who need it most.

Orenda Women's® includes a proprietary herbal blend called the O'Harmony Blend, six botanicals selected specifically to support hormonal balance and daily vitality in women.*

Dong Quai has been used in traditional wellness systems for centuries and is studied for its role in supporting healthy hormonal balance.* Black Cohosh and Chaste Tree (Vitex) are among the most researched botanicals for supporting hormonal equilibrium during perimenopause and menopause, and for supporting the natural hormonal fluctuations that occur throughout a woman's cycle.* Deodorized Garlic supports immune health and cardiovascular well-being.* Ginger supports digestive comfort and a balanced inflammatory response.* Evening Primrose Oil provides gamma-linolenic acid (GLA), a fatty acid that supports healthy skin and hormonal balance.*

Together, these six botanicals address the hormonal, digestive, immune, and skin-health dimensions of women's well-being in a single daily formula, support that goes meaningfully beyond what a standard multivitamin provides.*

Orenda Active® includes a proprietary herbal blend featuring two botanicals selected for their role in supporting the body's natural cellular stress response: Prickly Pear extract and Asparagus extract.*

Both ingredients are natural sources of compounds that support heat shock protein activity. Heat shock proteins are produced by the body in response to cellular stress, including the stress of exercise, environmental exposure, and everyday physiological demands. They play a role in stabilizing and supporting the repair of proteins under stress, helping maintain healthy cellular function over time.*

Prickly Pear extract is rich in antioxidants and has been studied for its role in supporting a balanced inflammatory response and healthy cellular resilience under stress.* Asparagus extract contributes additional antioxidant support and has been studied for its role in supporting healthy inflammatory balance and overall cellular protection.*

Together, these two botanicals address something most multivitamins overlook entirely: the cellular stress dimension of an active lifestyle. For men and women who push their bodies regularly, whether through exercise, demanding schedules, or environmental exposure, this blend supports the body's natural ability to respond and recover at the cellular level.*

The Orenda Ultimate Bundle was formulated with careful attention to safety. That said, if you are currently under medical care or taking any medications, we recommend consulting with your healthcare provider before adding any new supplement to your routine. Your healthcare provider understands your full health picture and is the right person to make that call with you.